Achieving scale-up technology for adherent culture

The final decision between adherent and suspension cell culture platforms must often be made by therapeutic developers to scale up production to meet demand. Each has advantages and disadvantages based on cell type, timing, desired yield, available production space and labor, cost, and other considerations.

Through collaborative research and development of innovative adherent culture amplification technology.Image credit: Photos

Systems that combine the productivity advantages of adherent cell culture with the scalability, automation, and control of suspension systems will be the ultimate strategy for a variety of applications.

For many years, Corning’s research and development teams have used its innovative processes to meet these requirements. Customer intimacy is the first step in this process, and it requires actively engaging customers to understand their problems, pain points and goals.

Corning field application specialists, sales representatives and scientific support professionals gather intelligence and discuss customer productivity issues and bottlenecks. To create viable solutions, they leverage Corning’s decades of materials science experience and deep understanding of cell biology and behavior.

Corning’s founding® rise® The FBR system is the latest example of this collaborative approach. This innovative fixed-bed bioreactor is designed to address the challenge of cost-effectively producing large numbers of adherent cells to support advanced therapies.

It is designed to provide significant surface area enhancement and high-yield biomanufacturing capabilities on a platform from benchtop process development to commercial production. Customer feedback throughout alpha and beta testing resulted in key design modifications resulting in a fully enclosed system with integrated controller, media conditioning vessel, bioreactor vessel and sensors.

About Corning Life Sciences

Corning Life Sciences, a division of Corning Incorporated, is the world’s leading manufacturer of cell culture products and solutions that enable academic, biotechnology and biopharmaceutical scientists to harness the power of cells to create life-changing innovations. Corning supports a range of application areas, including core cell culture, 3D cell culture, biological processes, cancer research, primary cell and stem cell research, drug discovery, cell and gene therapy, disease modeling, laboratory automation, and more.

Whether your goal is stem cell expansion or viral vector production, Corning’s life science platforms, including HYPERStack® Vessel that maximizes cell growth area in a small footprint, high yield Ascent® Fixed bed reactor platforms, microcarriers and closed system solutions can help you achieve your goals. Choose from hundreds of containers, the broadest selection of cell culture surfaces, and custom media in a variety of single-use technology configurations. For more information, visit

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